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    Treatment for Post-Thrombotic Syndrome (PTS)

    Post-thrombotic syndrome (PTS) is a condition caused by damage to veins from a blood clot. PTS can cause chronic pain, swelling, and other symptoms in your leg. It may develop in the weeks or months after a deep vein thrombosis (DVT) of the leg. DVT is a common condition, especially in people older than 65. Post-thrombotic syndrome affects a large number of people who have had DVT. It can happen in men and women of any age.

    Types of treatment

    Compression is the main treatment for PTS. It helps to increase the blood flow in the veins and ease your symptoms.

    You may be given prescription-grade compression stockings. These apply more pressure than the type you can buy over the counter. These are worn during the day, on the leg that had the DVT. You also may also be given an intermittent pneumatic compression (IPC) device. This device applies pressure on the veins of your leg.

    Proper skin care is also key. Your healthcare provider may tell you to use a product to lubricate your skin, such as petroleum jelly. Barrier creams that contain zinc oxide can also be helpful. You may need a steroid cream or ointment to treat your skin. If you develop leg sores (pressure injuries), they may need special treatment.

    In some cases, your healthcare provider may advise surgery. This can be done to remove a blockage in a major vein. It can also be done to repair the valves in your leg veins.

    Living with post-thrombotic syndrome

    Symptoms often get better with treatment, but your symptoms may not all go away. It may help if you:

    • Walk every day

    • Do daily ankle flexing exercises

    • Raise your legs for a period of time, several times a day

    Possible complications of post-thrombotic syndrome

    PTS can cause leg sores. If so, you will need to have wound care. Medicines such as aspirin, pentoxifylline, or stanozolol may help aid healing of pressure injuries. If a pressure injury becomes infected, you may need antibiotics. Severe pressure injuries that don't get better with medicines and wound care therapy may need surgery to remove the damaged tissue.

    Preventing post-thrombotic syndrome

    You can reduce your risk for PTS by lowering your risk for DVT. Not moving or walking for long periods of time raises your risk for DVT. If you are immobile because of a health condition or surgery, your healthcare provider will tell you how to prevent DVT. This may include:

    • Taking blood-thinner medicine, such as warfarin

    • Using compression stockings

    • Using a compression device

    • Moving and walking as soon as you are able

    Treating DVT right away is the best way to prevent PTS. Take blood-thinner medicine exactly as prescribed. Don't miss any follow-up tests to check your blood levels of the medicine. Use your compression devices exactly as prescribed.

    When to call the healthcare provider

    Call your healthcare provider right away if you have any of these:

    • A sore on your leg that is warm, red, or leaks fluid

    • Fever of 100.4°F ( 38°C) or higher

    • Symptoms of DVT, such as swelling, pain, or warmth in your leg

    Online Medical Reviewer: Deepak Sudheendra MD
    Online Medical Reviewer: Raymond Kent Turley BSN MSN RN
    Online Medical Reviewer: Ronald Karlin MD
    Date Last Reviewed: 12/1/2021
    © 2000-2026 The StayWell Company, LLC. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.
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    Southern New Mexico
    Surgery Center

    2301 Indian Wells Rd. Suite B
    Alamogordo, NM 88310
    www.snmsc.org

    Phone: 575.437.0890
    Fax: 575.437.0905
    Email: info@snmsc.org

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