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Penile Self-Injection: Notes and Precautions
Penile self-injection is a simple method that may improve your sex life. Some men even find that self-injection leads to an increase in natural erections. If you have questions or concerns about self-injection or erectile dysfunction (ED), talk with your health care provider. The information on this sheet will help you get the best results.
Notes about penile self-injection
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Know that you may feel a mild burning during injection. This is okay. But if you feel pressure or severe pain, stop the injection. There may be a problem with the injection site.
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Only inject the medicine on the side of your penis. It may not work if it's injected elsewhere.
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To prevent scarring, inject in a different spot each time.
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Don’t use this treatment if you have a bleeding disorder or any risk of infection.
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Go to the closest emergency room if your erection lasts longer than 3 to 4 hours. An erection lasting longer than 4 hours can cause serious damage to the penis and result in permanent ED.
Work with your doctor
Ask how often you can safely repeat injections, as well as any other questions you have. You and your health care provider will talk about follow-up exams and how to get supplies. If the medicine doesn’t work or stops working over time, tell your provider.
When to call your doctor
Go to the closest emergency room if your erection lasts longer than 3 to 4 hours. An erection lasting longer than 4 hours can cause damage to the penis and result in permanent ED.
Contact your health care provider right away if you have:
Online Medical Reviewer:
Melinda Murray Ratini DO
Online Medical Reviewer:
Rita Sather RN
Online Medical Reviewer:
Sravani Chintapalli
Date Last Reviewed:
2/1/2025
© 2000-2026 The StayWell Company, LLC. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.